Introduction LL-37, the only human cathelicidin antimicrobial peptide, emerges as a crucial player in our body's defense against infections. Originating from the CAMP (Cathelicidin Antimicrobial Peptide) gene, LL-37 is produced by various cells throughout the body, including epithelial cells and white blood cells. Its primary role lies in its potent antimicrobial activity, capable of destroying [...]
In a recent presentation, Dr. Aaron Miller of the Cleveland Clinic shared groundbreaking findings about oxalates, their interaction with the microbiome, and bile acids, drawing attention from Susan Owens and members who had the opportunity to engage in a Q&A session. I also did a video on the implications of oxalate and dysbiosis. Notably, Dr. [...]
The intricate interactions within our body's immune system, particularly involving mast cells, play a crucial role in inflammation and allergic reactions. These cells, when triggered by external substances (antigens), can cause inflammation and produce various chemicals that lead to allergic symptoms. Central to this process is a protein called spleen tyrosine kinase (Syk), which, when [...]
Genetic research has uncovered a specific gene mutation known as the cystathionine beta-synthase (CBS) mutation. This mutation accelerates the activity of the CBS enzyme, a crucial player in the transsulfuration pathway. This pathway, pivotal in liver function, oversees the conversion of homocysteine to cystathionine, leading towards the synthesis of either taurine or glutathione — but [...]
IC and Bladder Pain Syndrome In my clinical nutrition practice, I have come to really appreciate the role oxalates play in Bladder Pain Syndrome and Interstitial Cystitis. There are different viewpoints in the health community that debate the contribution that comes from dietary sources vs. the endogenous production. Most of the literature I have read [...]