The intricate interactions within our body's immune system, particularly involving mast cells, play a crucial role in inflammation and allergic reactions. These cells, when triggered by external substances (antigens), can cause inflammation and produce various chemicals that lead to allergic symptoms. Central to this process is a protein called spleen tyrosine kinase (Syk), which, when [...]
Genetic research has uncovered a specific gene mutation known as the cystathionine beta-synthase (CBS) mutation. This mutation accelerates the activity of the CBS enzyme, a crucial player in the transsulfuration pathway. This pathway, pivotal in liver function, oversees the conversion of homocysteine to cystathionine, leading towards the synthesis of either taurine or glutathione — but [...]
Recently it has come to my attention that there is a strong connection to fibrin, hypercoagulation, biofilms and the embedded infection associated with IC. It is a complex interaction of genetics and environmental influences that leads to this condition. One very strong environmental influence is are infections such as viruses or even their remedies. The [...]
What is histamine? Histamine is a signaling molecule that is used by your brain and also by your entire body (Anderson, 2023). Histamine is a biogenic amine that occurs to various degrees in many foods. Histamine (2-[4-imidazolyl]ethylamine) was discovered in 1910 by Dale and Laidlaw. It was identified as a mediator of anaphylactic reactions in 1932 (Maintz and Novak [...]
About thirty to forty percent of oxalate comes from the diet and the rest comes from what your body makes itself. This is of course, my opinion and of many other functional doctors I have consulted with over the years. Oxalic acid in the diet is first converted to glycolate, then glyoxylate, and then at [...]
Geek corner During the past two decades, there has been a rapid increase in studies that report associations with gene polymorphisms, nutrition and disease risk (Burdge, Hoile, & Lillycrop, 2012). This is a paradigm shift from traditional nutritional recommendations that have been based on age, sex, and pregnancy. The advances in the association with epigenetics [...]