Do you have a CBS Mutation?

Mar 14, 2024 | Detox, Evidence Based, Genetics, Science-Based, Wellness

Genetic research has uncovered a specific gene mutation known as the cystathionine beta-synthase (CBS) mutation. This mutation accelerates the activity of the CBS enzyme, a crucial player in the transsulfuration pathway. This pathway, pivotal in liver function, oversees the conversion of homocysteine to cystathionine, leading towards the synthesis of either taurine or glutathione — but not both simultaneously. Often, this rapid conversion skews towards taurine production at the expense of glutathione, a critical antioxidant that’s usually abundant in the body. Glutathione plays an essential role in numerous bodily processes, including immune response, detoxification, and supporting the activity of other antioxidants. The resulting shortfall in glutathione is a significant factor behind the recurrent bacterial, viral, parasitic, and fungal infections, increased cancer risk, and heightened sensitivity to toxic metals often observed in those with chronic illnesses. Insufficient glutathione means the body’s filtration and processing capabilities are compromised, leading to abnormal body functions.

In our Signature Root Cause Investigation program, we can identify these and other genetic mutations that can be greatly impact your health.  Read more below.

What does this enzyme do?

The cystathionine beta-synthase (CBS) enzyme plays a critical role in the transsulfuration pathway by facilitating the irreversible transformation of homocysteine into cystathionine, which is subsequently converted into cysteine. This process not only serves as an essential source of cysteine, an important amino acid, but also represents the body’s sole method for eliminating excess sulfur-containing amino acids.

CBS upregulation can cause sulfur dumping, increased taurine, increased sulfate and increased ammonia. Ammonia is neurotoxic and toxic the the bladder.

The activity of CBS is dynamically regulated based on the body’s levels of methionine and S-adenosylmethionine (SAMe). An abundance of methionine and SAMe prompts an upregulation of CBS, enhancing the transsulfuration process and thus, the conversion of homocysteine into cystathionine. Conversely, in conditions where methionine and SAMe are in short supply, CBS activity is reduced, leading to an increased activity of methionine synthase. This adjustment facilitates the remethylation of homocysteine back into methionine and SAMe, replenishing their stores. Specific single nucleotide polymorphisms (SNPs) have been identified that upregulate CBS activity, thereby favoring the transsulfuration pathway over remethylation processes.

The CBS gene is pivotal for producing the enzyme cystathionine beta-synthase (CBS), which utilizes vitamin B6 to transform the amino acids homocysteine and serine into a molecule named cystathionine. This enzyme plays a critical role in metabolizing homocysteine into either methionine or cysteine. Cysteine is a vital precursor to glutathione, an essential antioxidant, while methionine is crucial for DNA methylation and angiogenesis, the process of forming new blood vessels.

The CBS Mutation’s Effect on Health

Imagine the body’s metabolic system as a complex network of pathways, each designed to process and utilize various nutrients and compounds effectively. Within this network, the cystathionine beta-synthase (CBS) mutation introduces a profound challenge, akin to a “leaky bucket.” This analogy helps to visualize how, regardless of the efforts to nourish the body, essential nutrients, minerals, and antioxidants might be rapidly escaping, undermining health and wellness.

The CBS mutation accelerates certain enzymatic activities, leading to a situation where, alongside unwanted toxic substances, crucial nutrients and beneficial compounds are also being flushed out. This indiscriminate “dumping” process not only depletes the body of its valuable resources but also imposes a heavy burden on the liver and kidneys, which are tasked with filtering and eliminating these substances.

Moreover, the mutation triggers an overproduction of specific compounds like taurine, ammonia, sulfites, and hydrogen sulfide. While taurine is generally benign, the others pose significant toxic risks to the body. This scenario is further complicated by potential co-existing genetic variations, amplifying the mutation’s effects.

The consequences of this accelerated enzymatic activity extend beyond nutrient depletion. It can exacerbate gut health issues, contributing to an environment conducive to higher bacterial loads. This, in turn, can increase ammonia production and contribute to leaky gut syndrome—a condition where the gut lining becomes more permeable, allowing toxins and partially digested food to enter the bloodstream, potentially leading to food sensitivities and chronic inflammation.

Moreover, the mutation’s effects on the body’s ability to manage sulfur or sulfates can lead to an accumulation of toxic waste, alongside insufficient production of glutathione—the body’s master antioxidant. This deficiency in glutathione further compromises the body’s detoxification processes and antioxidant defenses.

One of the more alarming aspects of the CBS mutation’s impact is its potential to elevate glutamate levels significantly, leading to excitotoxicity. This phenomenon, where nerve cells are damaged or destroyed due to excessive stimulation by neurotransmitters like glutamate, highlights the mutation’s far-reaching implications on neurological health.  These people are the ones that generally feel worse when taking high doses of glutamine that are often prescribed by functional medicine doctors for gut health.

If that wasn’t bad enough..

The interplay between genetics and metabolic processes can have far-reaching effects on our health, particularly when it comes to the CBS (cystathionine beta-synthase) mutation. This genetic variation accelerates the conversion of homocysteine into cysteine and taurine, often at the expense of glutathione production. Glutathione, known as the body’s master antioxidant, is crucial for detoxification and protecting cells from oxidative stress. Instead, the CBS mutation triggers the enzyme G6PD, which plays a key role in maintaining red blood cell health and regulating blood sugar levels. This shift can lead to blood sugar imbalances throughout the day, potentially triggering or exacerbating a stress response.

Moreover, the gut’s communication with the adrenal glands means that any imbalance, such as those caused by CBS upregulation, can continuously activate the body’s fight-or-flight response. This can contribute to adrenal fatigue, a condition characterized by persistent tiredness, among other symptoms, as the body struggles to manage stress effectively.

The mutation’s influence extends to nutrient and toxin management, with the body becoming overwhelmed by substances like folic acid and folate triggered by CBS, further complicating the methylation cycle. This cycle is essential for DNA repair, detoxification, and the processing of hormones, vitamins, and neurotransmitters. Disruptions in this cycle can prolong symptoms of adrenal fatigue and other health issues.

Testosterone levels also play a role in the dynamics of the CBS mutation. In males, who naturally have higher testosterone levels, the mutation can exacerbate the dumping of nutrients and toxins. This highlights the importance of monitoring hormone levels for those with the CBS mutation. Additionally, maintaining balanced levels of essential minerals such as copper, zinc, molybdenum, and manganese is crucial. These minerals are integral to various bodily functions, including hormonal balance, enzyme activity, and antioxidant defense.

Understanding the complexities of the CBS mutation and its systemic impact is vital for managing its effects. It underscores the need for a holistic approach to health that considers genetic predispositions, diet, lifestyle, and hormonal balance. By addressing these areas, individuals with the CBS mutation can support their body’s natural processes, mitigate adverse effects, and promote overall well-being.

CBS Mutations

The fascinating realm of human genetics and metabolism showcases a delicate balance in enzymatic activities, including the transsulfuration pathway managed by the cystathionine beta-synthase (CBS) enzyme. Traditionally, decreased activity in the CBS pathway has captured scientific interest, particularly due to its association with conditions such as hyperhomocysteinemia and homocystinuria. Elevated homocysteine levels, a byproduct of this pathway’s disruption, have been linked to significant health concerns, including cancer and cardiovascular disease. Supplemental interventions like N-acetylcysteine (NAC), a precursor to the critical antioxidant glutathione, and betaine, backdoor to methylation, have been explored as methods to mitigate elevated homocysteine levels in certain cases.

However, the narrative around CBS pathway activity has expanded, revealing a spectrum of functionality where too much activity—referred to as “up-regulation”—poses its own set of challenges. This insight draws attention to the complex nature of physiological systems, governed by negative feedback mechanisms that aim for equilibrium yet can manifest in dualistic abnormalities: both excessive and insufficient levels.

To date, researchers have identified over 150 mutations within the CBS gene that lead to homocystinuria, a genetic disorder that affects the body’s ability to process the amino acid methionine properly. These mutations typically alter single amino acids in the CBS enzyme, impacting its function significantly.

One of the most prevalent mutations involves replacing the amino acid threonine with isoleucine at position 278 of the enzyme, a change known scientifically as Ile278Thr or I278T.


  • T allele is associated with higher CBS enzyme activity.
  • Upregulates the conversion of homocysteine to cystathionine, lowering homocysteine levels.
  • T allele is associated with an increased production of ammonia and taurine since they are major transsulfuration by-products. However, the degree to which these may accumulate and induce health problems is unclear.

Recent clinical observations and research have identified individuals with an inherent predisposition towards elevated CBS pathway activity. This up-regulation can occur in individuals with specific genetic mutations, including:

  • CBS C699T
  • CBS A360A
  • CBS N212N

Moreover, this heightened activity isn’t confined to those with a CBS mutation. Individuals exhibiting “down-regulations” in the BHMT pathway, characterized by mutations such as:

  • BHMT 1
  • BHMT 2
  • BHMT 4
  • BHMT 8

This enhanced pathway activity can lead to several metabolic alterations, including increased production of ammonia and urinary sulfates, alongside reductions in glutathione synthesis or disruptions in its redox balance.

Such mutations hinder the regular activity of the cystathionine beta-synthase enzyme, causing an accumulation of homocysteine and other potentially harmful substances in the blood and urine. Elevated homocysteine levels are associated with increased oxidative stress on blood vessel walls, contributing to the development of vascular plaque.

These mutations result in an upregulation or enhanced expression of the CBS enzyme, leading to excessive production of taurine and ammonia. This, in turn, tends to lower the levels of cystathionine and homocysteine, indicating that the CBS enzyme is overly active and prompting chemical reactions in the body that are abnormal and potentially harmful.

Ammonia and UTI

Excess ammonia in the urine can increase the urine pH, making it more alkaline, due to ammonia’s basic nature. Ammonia (NH3) is a byproduct of protein metabolism and is normally converted into urea in the liver, then excreted by the kidneys. However, when the body produces or excretes an excessive amount of ammonia, it can raise the pH of urine.

An alkaline urine environment can contribute to urinary tract infections (UTIs) for several reasons:

  1. Bacterial Growth: Many bacteria that cause UTIs, including Proteus mirabilis, thrive in an alkaline environment. These bacteria can convert urea into ammonia, further increasing the urine’s alkalinity and creating a favorable environment for their own growth and multiplication.
  2. Reduced Antibacterial Activity: Urine typically has natural antibacterial properties, part of which is due to its acidic pH. An increase in pH can diminish these antibacterial effects, reducing the body’s ability to inhibit bacterial growth.
  3. Crystal Formation: An alkaline urine pH can also lead to the formation of kidney stones, such as struvite stones, which are composed of magnesium, ammonium, and phosphate. These stones can harbor bacteria within them, protecting these pathogens from being flushed out of the urinary tract and from the effects of antibiotics. This can lead to persistent infections and can exacerbate the problem of UTIs.
  4. Changes in Urinary Composition: The shift towards a more alkaline environment can alter the composition of urine in ways that promote bacterial adhesion to the urinary tract’s lining. This makes it easier for bacteria to colonize and establish infections.

In the context of urinary tract infections (UTIs) and the overall urinary environment, it’s noteworthy that gram-positive bacteria, along with certain strains of Escherichia coli (E. coli), can indeed thrive in higher pH conditions. The increase in urine pH to more alkaline levels, such as around pH 7 or higher, creates a conducive environment for these microorganisms.

  1. Gram-Positive Bacteria: Many gram-positive bacteria, including certain staphylococci and enterococci, are well-adapted to survive and proliferate in alkaline environments. These bacteria possess cell wall structures that can withstand the variations in pH, allowing them to maintain cellular processes essential for their growth even as the urine pH increases.
  2. coli Strains: E. coli is a versatile bacterium with strains capable of thriving in a range of environments. While typically associated with a preference for neutral to slightly acidic conditions, certain strains have adapted to survive and even thrive at a urine pH of 7 or above. This adaptability is part of what makes E. coli a common culprit in UTIs. The ability to proliferate in alkaline urine not only facilitates the initial establishment of an infection but can also contribute to the persistence and severity of the infection.

The thriving of these bacteria in alkaline urine underscores the importance of maintaining a balanced urine pH as part of urinary tract health. Alkaline urine conditions can compromise the natural defense mechanisms of the urinary tract, promoting the establishment and persistence of bacterial infections. Managing factors that influence urine pH, such as diet and hydration, can be crucial steps in preventing UTIs and maintaining urinary tract health.

Addressing the underlying causes of excess ammonia production and excretion, such as liver dysfunction or a high-protein diet, can help manage and prevent the shift towards an alkaline urine pH and reduce the risk of infections.

Depletion of BH4

The CBS mutation has also been linked to the depletion of BH4 (tetrahydrobiopterin), a crucial cofactor involved in the synthesis of neurotransmitters like serotonin and dopamine, as well as thyroid hormones and melanin.  BH4 is also a cofactor for inducible nitric oxide and endothelial nitric oxide as well. Furthermore, BH4 plays a vital role in detoxifying ammonia from the body. Its significance extends to the regulation of neurotransmitters and mood, highlighting the potential for wide-ranging impacts on health due to BH4 depletion.

Compounding the issue, other genetic mutations such as MTHFR A1298C, along with chronic bacterial infections and exposure to aluminum, have been identified as factors that can further diminish BH4 levels. Maintaining balanced BH4 levels is crucial, as a deficiency can trigger mast cell degranulation or contribute to mast cell activation disorder (MCAD), conditions marked by an excessive release of mast cell mediators, leading to a variety of symptoms and allergic responses

The upregulation of CBS not only disrupts the normal functioning of the transsulfuration pathway but also poses a significant challenge to the urea cycle by depleting BH4 and exacerbating the cycle’s workload. This imbalance underscores the importance of monitoring and managing BH4 levels, especially in individuals with CBS mutations, to mitigate potential adverse health effects associated with BH4 depletion and urea cycle overload.

Sulfur intolerance

Having a cystathionine beta-synthase (CBS) mutation can indeed result in an excess amount of taurine in the system, but it also leads to an increased amount of sulfur. This is significant because sulfur plays a crucial role in various metabolic processes, yet an overload can stress the body, especially in systems already compromised by conditions like Adrenal Fatigue Syndrome (AFS). In AFS, the body’s response to stress is impaired, often resulting in a cascade of symptoms such as fatigue, sleep disturbances, and more. An excess of sulfur can exacerbate these symptoms by further burdening the body’s detoxification pathways.

For individuals with a CBS mutation, managing sulfur intake is essential to avoid overwhelming their system. While it’s advisable to limit the intake of high-sulfur foods, not all sources of sulfur have the same impact:

  • Complex Sulfur from Herbs: Herbs like horsetail grass, spirulina, dandelion leaf, or parsley contain complex forms of sulfur. These are generally considered safer options for individuals with CBS mutations. The sulfur in these herbs is part of larger, complex molecules that the body can process more gently, without causing the same level of stress as simpler sulfur compounds.
  • High-Sulfur Foods: In contrast, foods that are high in simpler sulfur compounds, such as cruciferous vegetables (e.g., broccoli, cauliflower, cabbage), alliums (e.g., garlic, onions), and animal proteins, might need to be consumed in moderation. These foods release sulfur in a more readily available form, which can contribute to the overload and stress on the detoxification system.

Cravings for sulfur-rich foods, an aversion to them, or a sensitivity could indeed be indicative of a CBS (cystathionine beta-synthase) upregulation. This genetic variation accelerates the conversion of homocysteine to cystathionine, potentially leading to an excess of sulfur in the body. Understanding the sources of sulfur and how they interact with a CBS mutation is crucial for managing symptoms and maintaining health.

Sources of Sulfur in the Context of a CBS Mutation:

  • Taurine: An amino acid that supports cardiovascular function, development, and function of skeletal muscle, the central nervous system, and the cardiovascular system. Excess can exacerbate sulfur overload.
  • Cruciferous Vegetables: Such as broccoli, are high in sulfur and can contribute to sulfur accumulation if not balanced properly.
  • Alliums: Garlic and onions are rich in sulfur compounds, which may need moderation in those with CBS mutations.
  • Coconut Products: Coconut milk and oil contain sulfur, albeit in smaller amounts compared to other sources.
  • Antioxidants and Supplements:
    • Glutathione and N-Acetylcysteine (NAC): Act as antioxidants and precursors to glutathione, the body’s primary antioxidant. Their use should be carefully considered.
    • SAMe: A compound involved in methylation processes that can influence sulfur metabolism.
    • Magnesium Sulfate Cream and Epsom Salts: Used topically, these can introduce additional sulfur through the skin.
    • Milk Thistle, Glucosamine Sulfate, Chondroitin Sulfate, MSM: Supplements often used for liver support and joint health, containing high sulfur levels.
    • Alpha Lipoic Acid (ALA): A powerful antioxidant that can influence sulfur balance.
  • Detoxification Agents:
    • DMPS, DMSA: Chelating agents used to remove heavy metals but also increase sulfur levels.
    • Heparin: A medication with sulfur that can affect individuals with CBS mutations.

In individuals with normal CBS function, sulfur is effectively bound to amino acids and utilized or excreted safely. However, with a CBS upregulation, this process is disrupted, leading to the potential accumulation of sulfites and other sulfur metabolites, which can exacerbate symptoms such as gas, bloating, or sensitivity to sulfur-containing foods and supplements.

For those with a CBS mutation, it’s important to be mindful of dietary sulfur intake and the use of sulfur-containing supplements. Adjusting these can help manage the overabundance of sulfur and mitigate related health issues. Consulting with healthcare professionals familiar with CBS mutations and sulfur metabolism can provide personalized guidance for dietary and supplement decisions, ensuring a balanced approach to sulfur intake and overall health.


It’s crucial to understand that variations in CBS (cystathionine beta-synthase) activity—whether unusually high or low—may not always be present in individuals with genetic mutations affecting CBS or BHMT enzymes. Nonetheless, those carrying mutations in these genes tend to be more susceptible to alterations in the CBS pathway, potentially leading to up-regulations that can impact various metabolic processes.

To discern or confirm up-regulation of the CBS enzyme, the following laboratory findings can be insightful:

  • Presence of CBS and/or BHMT gene mutations.
  • Urinary sulfates exceeding 800, with values consistently above 1000 suggesting heightened CBS activity.
  • Elevated ammonia and/or sulfate levels observed in an Metabolomix.
  • Increased B6 levels in an OAT, which may indicate CBS up-regulation.
  • High urinary Taurine values, hinting at cysteine synthesis via the CBS pathway.
  • Elevated orotate, citrate, and isocitrate in an Nutreval, indicating increased ammonia levels.


Additionally, based on clinical observations, the following standard blood test results may correlate with CBS pathway up-regulations:

Elevated BUN (Blood Urea Nitrogen) levels, exceeding 20, can signal various health concerns, including kidney dysfunction or dehydration. In individuals with CBS (cystathionine beta-synthase) gene mutations, this elevation might arise from an excess of ammonia funneling into the urea cycle, showcasing a unique metabolic challenge related to this genetic variation.

Increases in ALT (Alanine Aminotransferase), especially when values surpass 30, point to metabolic stress within the body. ALT, an enzyme present in multiple organs and tissues, usually becomes elevated due to liver stress or injury. In the context of a CBS mutation, such elevations may be attributed to the body’s response to increased ammonia levels, stemming from the mutation’s effects on amino acid processing.

Remarkably low homocysteine levels, often falling below 6, can serve as a significant marker of CBS upregulation. This abnormality results from homocysteine being rapidly diverted into the transsulfuration pathway, where the CBS enzyme operates. Instead of maintaining a balanced level, homocysteine is excessively converted, leading to a shortage and indicating a potentially hyperactive CBS enzyme activity.

Further indications of CBS up-regulation might include unusual cravings for or sensitivity to sulfur-rich foods, or behavioral changes following L-Glutamine intake, potentially due to increased ammonia levels related to CBS activity.

Understanding these nuances allows for a more targeted approach to managing health, especially in individuals with CBS or BHMT mutations. It underscores the importance of a comprehensive assessment, incorporating genetic insights with traditional and functional laboratory findings, to devise personalized health strategies.  In my Root Cause investigation program, we do various labs such as Nutreval/OAT testing, Hair tissue mineral analysis, Genetic testing, Blood chem and others where you can identify if a CBS mutation is contributing to your health issues.

>>>>Here is a snap shot of some of the labs we offer <<<<<

Copper toxicity anyone?

CBS upregulation, a genetic variation affecting the transsulfuration pathway, can have a ripple effect on mineral balance in the body, notably leading to elevated copper levels. Excess copper, while essential in small amounts for health, can disrupt various bodily systems when unregulated. I review Copper imbalances in this Youtube Video that I did.

  • Blood Health: Elevated copper may cause iron deficiency anemia by interfering with iron absorption and metabolism, leading to symptoms of fatigue and weakness.
  • Liver Function: Excessive copper can accumulate in the liver, potentially leading to conditions such as Wilson’s disease, which impairs the organ’s ability to function properly.
  • Immune System: High copper levels can weaken the immune system, making the body more susceptible to infections and slowing down the healing process.
  • Thyroid Health: Copper overload can contribute to thyroid problems, including hypothyroidism, affecting metabolism and energy levels.
  • Mental and Emotional Well-being: The nervous system can be affected by copper imbalance, leading to mood disorders such as depression, anxiety, and aggression. It may also impact cognitive functions, contributing to learning disabilities.
  • Reproductive Health: Hormonal imbalances, particularly in the reproductive system, can manifest as premenstrual syndrome (PMS) and other menstrual irregularities.
  • Adrenal Gland Function: The adrenal glands, crucial for stress response and metabolism, may become weakened, leading to adrenal fatigue and insufficiency.
  • Digestive System: Gastrointestinal issues like constipation and gastritis can arise, complicating nutrient absorption and overall digestive health.
  • Musculoskeletal System: An imbalance in copper can affect the body’s ability to maintain healthy bones, joints, and connective tissues, potentially leading to conditions like osteoarthritis and scoliosis.
  • Cholesterol Levels: Copper excess may influence lipid metabolism, contributing to elevated cholesterol levels and increasing cardiovascular risk.
  • Gallbladder Health: Gallstone formation can be exacerbated by copper imbalance, affecting bile flow and digestion.
  • Fertility– I discuss this in detail in this blog. 

To identify copper toxicity effectively, incorporating hair tissue mineral analysis (HTMA) and blood chemistry testing can be invaluable.

We can check copper toxicity in both the HTMA Supercharged Program and the Root Cause Investigation program.

HTMA provides a comprehensive view of mineral balances and heavy metal toxicity over a longer period, making it useful for detecting chronic copper exposure. When combined with blood chemistry tests, which can reveal immediate levels of copper as well as ceruloplasmin and liver function indicators, a more complete assessment of copper status and potential toxicity is achieved. By analyzing both tissue and blood samples, you can identify patterns of copper accumulation and assess how it’s affecting bodily functions, leading to a more targeted and effective treatment plan. This dual approach allows for a nuanced understanding of copper’s impact on health, guiding dietary, lifestyle, and supplementation decisions to restore balance and mitigate toxicity symptoms.

Other effects of CBS mutations

The CBS mutation, influencing the transsulfuration pathway, may lead to a variety of health challenges that manifest differently across individuals. Here’s a closer look at potential issues associated with this genetic variation:

  • Zinc Deficiency: Low zinc levels can cause a decreased sense of taste and smell, frequent infections, reduced skin elasticity, fertility issues, and skin conditions like acne.
  • Homocysteine Fluctuations: While some individuals may experience low homocysteine levels, leading to sleep disturbances and possible hypertension, others might face an increased risk of cardiovascular issues.
  • Sleep Disruptions: Problems with sleep quality and duration can stem from altered biochemical pathways due to the CBS mutation.
  • Oxidative Stress: An imbalance between free radicals and antioxidants in the body can lead to cellular damage and chronic health conditions.
  • Digestive Concerns: Stomach issues, including indigestion and bloating, may be more prevalent in individuals with the CBS mutation.
  • Blood Pressure Variations: Increased hydrogen sulfide can cause dizziness and lower blood pressure, while alterations in homocysteine levels might lead to hypertension.
  • Neurotransmitter Imbalances: A BH4 deficiency, critical for neurotransmitter synthesis, can result in mood disorders such as depression, anxiety, and panic attacks.
  • Molybdenum Deficiency: This rare condition can lead to breathing difficulties and neurological symptoms due to molybdenum’s role in enzyme functions.
  • Vitamin B1 (Thiamine) Deficiency: Insufficient thiamine can cause symptoms ranging from muscle tenderness and rapid heartbeat to poor memory and irritability.
  • Vitamin B2 (Riboflavin) Deficiency: This may manifest as cracked lips, split nails, skin issues, and eye problems like sensitivity to light.
  • Vitamin B6 Deficiency: Insufficient B6 can lead to water retention, tingling in the hands, mood disturbances, and muscle issues.

Addressing these issues involves a comprehensive approach, including dietary adjustments to ensure adequate intake of essential vitamins and minerals, possibly supplementation to correct specific deficiencies, and lifestyle modifications to support overall health. Understanding the unique impacts of the CBS mutation enables individuals and healthcare providers to tailor interventions for optimal health outcomes.

Managing a CBS mutation

Managing a CBS mutation and its implications for health requires a multifaceted approach focusing on dietary adjustments, supplementation, and lifestyle modifications to address potential gut issues and support detoxification:

  • Moderate Protein Intake: Opt for a balanced diet with moderate protein levels to avoid exacerbating the body’s ammonia production.
  • Gradual Introduction of CBS/NOS Support: Begin with a small fraction of a CBS/NOS capsule daily, carefully increasing the dosage up to two capsules a day to aid the urea cycle while minimizing detox side effects.
  • Incorporate Spirulina: Adding spirulina to your diet can help alkalize the body and facilitate ammonia detoxification due to its nutrient-rich profile.
  • Balance Minerals with Molybdenum and Manganese: These minerals can help maintain optimal copper and zinc levels in the body and assist in reducing sulfite accumulation.
  • Curcumin Supplementation: Known for its anti-inflammatory properties, curcumin can also enhance glutathione levels, supporting detoxification processes.
  • Ammonia Management: If high ammonia levels persist, consider Ammonia RNA or L-carnitine supplements to aid in its reduction.
  • Charcoal Flushes for Ammonia: Activated charcoal can be used to absorb excess ammonia, followed by magnesium citrate flushes 1-2 times weekly to aid in elimination and maintain bowel health.

ZEOCHARGE to the rescue

Zeolite, a naturally occurring mineral with a unique, microporous structure, is renowned for its ability to bind and remove toxins from the body, including excess ammonia. Its crystalline framework allows it to act like a sponge, absorbing harmful substances and effectively reducing their impact on health. This makes zeolite, particularly products like ZeoCharge, an invaluable tool in detoxification protocols, especially for individuals dealing with conditions that lead to elevated ammonia levels, such as CBS mutations. By incorporating ZeoCharge into your wellness routine, you can leverage zeolite’s powerful ammonia-binding properties to support detoxification processes, enhance liver function, and promote overall health. Its natural, non-invasive approach to removing toxins makes it a preferred choice for those seeking to reduce ammonia and other toxic burdens in the body safely and effectively.  Use the coupon ICHealer for 10% discount.


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Tailoring your health strategy to address the specific challenges of a CBS mutation can significantly improve overall well-being, reduce symptoms associated with sulfur and ammonia imbalances, and enhance detoxification processes. Always consult with a healthcare professional before starting new supplements or making significant dietary changes to ensure they are appropriate for your individual health needs.


For more information on how you can identify your imbalances that may be contributing to your symptoms, visit my Root Cause investigation program. 

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