Alleviate Bladder Pain with Resveratrol and Curcumin

Mar 9, 2024 | Inflammation, Oxalate, Science-Based, Supplements

If you’re battling Interstitial Cystitis or Bladder Pain Syndrome, understanding the role of oxalates and their impact on your condition is crucial. Oxalates, found in various foods and produced in our bodies, can worsen bladder symptoms. Interestingly, research reveals that exposure to oxalate crystals can significantly increase levels of TGF-beta, a protein linked to inflammation and tissue damage, which we also see elevated in individuals exposed to mold. This elevation is concerning because several types of mold, particularly strains of Aspergillus, can produce oxalates, potentially raising the risk for those frequently consuming high-oxalate foods.

Intriguingly, a study highlighted how exposure to calcium oxalate monohydrate crystals can disrupt cellular health, notably by reducing vital proteins that keep cell layers tightly joined. This weakening of cellular bonds could lead to increased bladder vulnerability and discomfort.

Oxalates in the diet

Dietary habits could inadvertently contribute to these challenges. For instance, a case highlighted a patient with unexplained fatigue and eczema, common signs of elevated TGF-beta, which improved dramatically after cutting out high-oxalate smoothies and nuts from her diet. This improvement underscores the significance of oxalates in exacerbating symptoms and the potential benefit of dietary modifications.

Lipid Peroxidation

Cooking methods that increase the risk of lipid peroxidation, like frying, can lead to higher oxalate production in the body, compounding the issue. I talk about this in this blog here. This production chain starts with lipid peroxidation creating glyoxal, a precursor to both oxalates and harmful compounds like carboxymethyllysine, highlighting the intricate relationship between diet, cooking methods, and bladder health.

To safeguard your health, reconsidering dietary choices, particularly the intake of high-oxalate foods and the types of fats consumed, can be a pivotal step. Emphasizing antioxidants in your diet can also counteract oxidative stress, potentially reducing oxalate production and alleviating symptoms.


Oxidative damage to kidney cells caused by an excess of oxalates is a key factor behind the formation of kidney stones, particularly those made of calcium oxalate. Interestingly, Resveratrol (RSV), a natural compound found in red wine, grapes and berries, has been shown to protect kidney cells from this type of damage. A crucial part of Resveratrol’s protective ability seems to hinge on autophagy, a cellular clean-up process.

Research delves into how Resveratrol combats oxidative damage in kidney cells caused by oxalates and explores the pivotal role of autophagy in this protective mechanism. In experiments with rats induced with oxalate-related kidney conditions, Resveratrol treatment was found to reverse the harmful effects typically observed, such as cell damage, inflammation, and the deposition of calcium oxalate crystals.

Resveratrol was observed to boost cell health, diminish oxidative stress, and prevent the transformation of cells in ways that could lead to stone formation. It also promoted autophagy markers in kidney cells, indicating that enhancing this cellular process is a key strategy in preventing kidney stone formation and oxidative damage.

Given the global prevalence of kidney stone diseases and their significant health and economic burdens, understanding and harnessing the protective effects of compounds like Resveratrol through mechanisms like autophagy could offer promising avenues for prevention and treatment.

This underscores the importance of dietary choices and potentially supplements in managing health conditions like kidney stones, highlighting the need for further research into natural compounds and their benefits.

While berries are a delicious and healthy addition to any diet, it’s worth noting that they are also high in oxalates, which can contribute to kidney stone formation in susceptible individuals. Red wine also contains alcohol, which can be problemtic for several reasons. Alcohol can promote fungal overgrowth. It can also deplete B1, which is a vitamin needed to metabolize and remove oxalate from the body. And it can also deplete DAO enzyme, which is required to break down histamine in the gut.

However, the power of natural compounds like Resveratrol, found in grapes and berries, and Curcumin, from turmeric, in combating inflammation and oxidative stress is undeniable. To harness these benefits without the high oxalate content of certain foods, consider innovative supplements like the liposomal formulation of Resveratrol and Curcumin offered by Desbio.

You can purchase this product by visiting the store here.

The Anti-Inflammatory Benefits of Resveratrol and Curcumin

Resveratrol: This compound is renowned for its ability to reduce inflammation and protect against oxidative stress, which can lead to cellular damage and chronic diseases. It’s particularly effective in safeguarding kidney cells from the oxidative injury caused by high oxalate levels.

Curcumin: Known for its potent anti-inflammatory properties, Curcumin can inhibit the molecules involved in inflammation, offering relief and protection against conditions like arthritis, heart disease, and even certain cancers.

Why Liposomal Formulations?

Liposomal formulations encapsulate Resveratrol and Curcumin in a lipid layer, enhancing their absorption and bioavailability. This means the body can utilize these compounds more effectively, maximizing their health benefits. Liposomal supplements are particularly beneficial for substances like Curcumin, which traditionally has low bioavailability due to its poor absorption, rapid metabolism, and rapid elimination

Desbio’s Liposomal Resveratrol and Curcumin

Desbio is at the forefront of offering a liposomal formulation that combines Resveratrol and Curcumin, providing a powerful anti-inflammatory and antioxidant supplement. This product is designed to:

  • Enhance absorption and ensure that these potent compounds reach the cells where they’re needed most.
  • Offer a convenient alternative to consuming high-oxalate foods for those seeking the benefits of Resveratrol and Curcumin without the potential downside.
  • Support overall health by combating oxidative stress, reducing inflammation, and potentially lowering the risk of chronic diseases.

By choosing Desbio’s liposomal Resveratrol and Curcumin, you’re not only opting for superior absorption but also tapping into the synergistic effects of these two powerful anti-inflammatory agents, all while minimizing dietary oxalate intake. Explore this innovative supplement as a proactive step toward maintaining optimal health and preventing the complications associated with oxidative stress and inflammation.

For a comprehensive understanding and tailored nutritional advice, consider undergoing a Nutreval test. This detailed analysis can pinpoint whether high oxalate levels in your system stem from dietary sources, oxidative stress, lipid peroxidation, or even genetic factors, guiding you towards effective interventions for relief. Please visit the Root Cause Investigation to learn more about how you can investigate your Root Causes.

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